Cell-based regenerative medicine

Genetically engineered neural precursor cells for cell-based therapies of myelin disorders

Generation of transplantable human ES cell-derived neural precursors with enhanced migration and integration potential
Application of migration enhanced cells in an animal model of a lysosomal storage disease and identification of novel migration stimulating factors

Sorting of stem cell subpopulations and regulation of their differentiation potential by extracellular matrix components and using integrins to select and engineer stem and precursor cells for enhanced repair capacity 

Therapeutic potential of adult neural stem cells in cases of cerebral ischemia

Transduction of exogenous neuronal SC using neuroprotective fusion proteins: effects on SC survival and differentiation after transplantation following focal cerebral ischemia

Regenerative potential of neural-induced mesenchymal stem cells after stroke

Suicide-gene mediated cell ablation for the use of ES-cells for therapy of Parkinson’s disease

Cultured multipotent adult progenitor cells for cell therapy of Parkinson’s disease

Adult endogenous neurogenesis in Parkinson’s disease

Grafting of dopamine producing cells and behavioural testing in a rat model of Parkinson’s disease; survival and tumorogenic potential of these cells

Measurement and targeted manipulation of the cell-differentiating environment during the cultivation of human hair follicle stem cells

Analyses of ECM proteins expressed in the mouse hair stem cell niche

01GN0520
591.756 EUR
01.09.2005 - 28.02.2009

Generation of vascular networks in bioartificial cardiac tissue (Engineered Heart Tissue (EHT) using tissue resident progenitor cells and macrophages

Development of Artificial Myocardial Tissue with functional large diameter vessels using a vascularized Matrix Based on small intestinal submucosa

Gene and protein marker profile of human mesenchymal stem cells

Cardiovascular differentiation of MSC and application studies

Characterization and quality control of hepatocytes and putative hepatic progenitor cells by standardized analysis of hepatic lineage markers and cellular hepatic function

Characterization and production of monoclonal antibodies for cell fate mapping, monitoring and preparative enrichment of cardiomyogenesis and hepatogenesis 

Platform for the generation of reprogrammed tetraploid and diploid cells via fusion with mouse embryonic stem cells (ESC) 

In vitro elektrophysiologische und immunologische Charakterisierung der embryonalen Stammzellen fusioniert mit Maus-Herzzellen

Characterization of the tumorigenic potential and the immunogenicity of reprogrammed cardiomyocytes in vivo

Platform for gene expression profiling of reprogrammed tetraploid and diploid ESC hybrids

Consortium: Mesenchymal Stem Cells as a cellular therapeutic tool to induce immunological tolerance and improve allograft survival

Network: "Tissue engineering of human heart valves using umbilical cord cells"  

Analysis of the beneficial influence of the neural adhesion molecule L1 on migration of neural precursor cells and interaction with demyelinated axons

Georg-August-Universität Göttingen
Zentrum Innere Medizin
Abt. Kardiologie und Pneumologie
Robert-Koch-Str. 40
37075 Göttingen
Prof. Dr. Gerd Hasenfuß

Pluripotent adult spermatogonial stem cells – Establishment of procedures for human tissues and development of therapy approaches

01GN0601
613.252 EUR
01.10.2006 - 31.12.2007