2. b) State of funding program (2. call)
The second call was published on December 5th, 2007 and 16 draft proposals were submitted. In course of the initial evaluation by an international review board in August 2008, five IFB concepts were identified as most promising and the respective applicants were invited to submit full proposals. All five applicants convinced their respective interdisciplinary international review board during the onsite evaluation meeting and were therefore recommended for funding. The IFB of the second round have started with the implementation of their concepts in 2009/ 2010.
3. Funded integrated research and treatment centres
Comprehensive Heart Failure Centre Würzburg
|
Universitätsklinikum Würzburg
Medizinische Klinik und Poliklinik I
Josef-Schneider-Str. 2
97080 Würzburg |
Principal investigator:
Tel.:
Project number:
Volume:
Funding period:
|
Prof. Dr. Georg Ertl
+49 931 201-39001
01EO1004
24.523.937 EUR
01.11.2010 - 31.10.2015 |
Heart failure is a most rapidly growing health care problem. Two to three millions of patients with heart failure are currently living in Germany; the condition affects approximately one out of ten elderly above 70 years. Prognosis is as grim as in many malignancies. Physical performance of the patients may be severely limited and their quality of life seriously compromised. Repeated hospitalisations are frequent and costly. Various diseases may cause heart failure: hypertension, coronary artery disease, cardiomyopathies, valvular disease and others. Heart failure and its complications thus concern the whole organism. Stroke, renal failure, anemia, cerebral dysfunction, depression and sudden cardiac death are frequent consequences. An interdisciplinary approach is, therefore, mandatory in research, teaching and patient care. The IFB is designed to develop into a Comprehensive Heart Failure Centre (CHFC) of excellence which will be unique in Germany. The CHFC will enhance and coordinate existing top-level basic, translational and clinical research activities. Theoretical institutes will to this end cooperate with clinical departments. The principal objective of the CHFC is to prevent heart failure and its complications in patients with cardiovascular risk factors or diseases. This approach aims to implement preventive strategies at any level of the disease continuum eventually leading to development and progression of heart failure. It will further develop innovative concepts in diagnostics and clinical management as well as new therapeutic strategies which intervene early in the healing and remodelling processes of the heart. Comorbidities are of paramount importance in heart failure, yet were in the past neglected in research; thus, their pathophysiological role and their impact on progression and outcome will be another high priority topic. In order to succeed in these ambitious endeavours, research at the CHFC will be organised in project areas, which represent the most important structural subunits of the CHFC for the implementation, coordination, performance and advancement of interdisciplinary research and treatment.
Center for Thrombosis and Hemostasis (CTH) Mainz
|
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Centrum für Thrombose und Hämostase (CTH)
Langenbeckstr. 1
55131 Mainz |
Principal investigator:
Tel.:
Project number:
Volume:
Funding period:
|
Prof. Dr. Thomas Münzel
+49 6131 17-5737
01EO1003
15.400.032 EUR
01.09.2010 - 31.08.2015 |
The aim of the “Center for Thrombosis and Hemostasis (CTH)” is to improve research and treatment of thrombosis and hemostasis diseases. Therefore, a national reference center will be established using exemplary, interdisciplinary and integrative structures. The translational interaction between basic researchers and clinicians will stimulate innovations in diagnostics and therapy. A structured program for young scientists/researchers will provide attractive career perspectives at the intersection of science and clinic. Perspectively the CTH will promote a sustainable focus on the areas of thrombosis/hemostasis in Mainz. The structure of the CTH covers modules dealing with translational-, experimental- and epidemiological research as well as clinical studies, patient care, education and training, and management and administration. These CTH modules are strongly linked to each other. The CTH operates and takes responsibility for its activities in science and patient care as an independent center. Through its far-reaching independence the CTH aims to optimize the ability to act in science and clinic. Thus it makes use of strategic project support, focus of its research program and new concepts in patient care in order to react quickly to important scientific/clinical impulses and demands. The CTH establishes the necessary structures in the frame of a model project. The results will also provide orientation for the structural adjustment of other areas of the University hospital and other facilities and organizations that are comparable to the CTH. The CTH’s sustainability as independent clinical-scientific facility is secured by the gradual conversion of funded structural elements into basic funding. Furthermore, specific utilization and sustainability concepts for additional funding will be developed.
Center for Sepsis Control and Care (CSCC)
|
Universitätsklinikum Jena
Klinik für Anästhesiologie und Intensivtherapie
Erlanger Allee 101
07747 Jena |
Principal investigator:
Tel.:
Project number:
Volume:
Funding period:
|
Prof. Dr. Michael Bauer
+49 3641 9323101
01EO1002
22.999.503 EUR
01.08.2010 - 31.07.2015 |
Sepsis is a disease that jeopardizes progress in high-end medicine. Moreover, it implicates immense medical and socioeconomic relevance: the costs for acute therapy on the intensive care units account for 1.7 billion Euro per year. Mortality of severe sepsis is unchangingly high with rates exceeding 50%, i.e. every second sepsis-patient will die of it. In Germany, every year, 220 new patients per 100.000 residents suffer from sepsis - heart attacks are comparably frequent. This number is likely to rise, since changes in demography along with increasing numbers of invasive procedures performed in elderly patients will lead to an increasing number of patients. Overall, there is a lack of knowledge about its considerable long-term sequelae. This unsatisfactory situation can only be improved if sepsis is better prevented, diagnosed earlier, and treated more successfully in the acute and post-hospital phase. It is therefore the mission of the "Center for Sepsis Control and Care" (CSCC) to contribute significantly towards a reduction of the incidence of sepsis and the quality of acute and long-term care of sepsis patients. This requires novel approaches and improvements in sepsis research including risk assessment and prevention, new diagnostic tools as well as health care and treatment. The CSCC will combine sepsis research and treatment under these topics. New career options for physicians and basic scientists are implemented. Clinicians are offered a clear time allocation for clinical duties and protected time for education and research. Furthermore, excellent Junior and Senior Research Groups will be embedded interdisciplinary in the CSCC. Core units will include a comprehensive CSCC Trials Center as well as the CSCC Biobank. Physicians and scientists will thus be enabled to closely cooperate within novel organisational structures characterized by a flat hierarchy to tackle all aspects of the disease course from risk prediction to long-term sequelae and rehabilitative care to reduce mortality, improve quality of life in survivors and decrease the economic burden of sepsis.
Integrated Research and Treatment Center AdiposityDiseases
|
Universität Leipzig
Medizinische Fakultät
Liebigstr. 27
04103 Leipzig |
Principal investigator:
Tel.:
Project number:
Volume:
Funding period:
|
Prof. Dr. Michael Stumvoll
+49 341 9713380
01EO1001
23.907.982 EUR
01.05.2010 - 30.04.2015 |
Obesity and associated diseases are one of the greatest medical challenges of our time. With the Integrated Research and Treatment Center (IFB) AdiposityDiseases, the University of Leipzig, the Medical Faculty, and the collaborating University Hospital will create a unique and outstanding clinical research and treatment centre which not only focuses on one of the most prevailing and challenging health problems with paramount medical and socioeconomic importance but also concentrates research and care within a novel organisational structure. Within the IFB the pathology of patients with adiposities will be systematically investigated. By conducting clinical trials diagnostic instruments will be further developed and a rationalized approach to prevention and therapy of adiposity diseases established. Further, an interdisciplinary standardized approach to diagnose and treat obesity and associated diseases will be developed by involving all levels of diagnostics, therapy and care of IFB patients in parallel research structures. Special attention will be granted to the structured advancement of physician scientists.
The IFB AdiposityDiseases will become a model institution for the promotion of young researchers and - in particular - of physician scientists. In the long run, the IFB aims at becoming an internationally recognized centre of excellence in the field of obesity research and treatment.
Integrated Research and Treatment Centre for Vertigo, Balance and Ocular Motor Disease
|
Ludwig-Maximilians-Universität München
Medizinische Fakultät
Neurologische Klinik und Poliklinik
Friedrich-Baur-Institut
Marchioninistr. 15
81377 München |
Principal investigator:
Tel.:
Project number:
Volume:
Funding period:
|
Prof. Dr. Thomas Brandt
+49 89 7095-2380
01EO0901
24.277.530 EUR
01.11.2009 - 31.10.2014 |
Vertigo is one of the most frequent complaints bringing patients to a doctor. Although its causes can usually be clarified and the patients successfully be treated, medical care of this disorder is unsatisfactory in German and throughout the world. Many patients undertake a veritable Odyssey through departments of various medical specializations before receiving a correct diagnosis and appropriate treatment. Consequently too many unnecessarily developed chronic problems are caused being psychologically, socially and economically very costly. The Integrated Research and Treatment Centre for Vertigo, Balance and Ocular Motor Disease (IFBLMU) is conceived as an interdisciplinary, patient-oriented research centre that over the long term will become a leading international reference centre. Central units of the IFBLMU include the Outpatient Dizziness Clinic, the Clinical Study Centre, a Teaching and Training Module, and ongoing scientific cooperation with several clinics. Within the IFBLMU young scientist will have the chance to work independently at an early stage in their career and attractive career perspectives will be provided e.g. by the implementation of junior research groups and research professorships. Flat hierarchies and the novel organisational structure will enable young academics to take active part in decision making processes with regard to the scientific orientation of the IFBLMU.
Center of Chronic Immunodeficiency (CCI)
|
Albert-Ludwigs-Universität Freiburg
Universitätsklinikum
Centrum für Chronische Immundefizienz (CCI)
Hugstetterstr. 55
79106 Freiburg |
Principal investigator:
Tel.:
Project number:
Volume:
Funding period:
|
Prof. Dr. Stefan Ehl
+49 761 270-4309
01EO0803
24.974.562 EUR
01.08.2008 - 31.10.2013 |
Chronic immunodeficiency, whether primary or acquired, represents an outstanding multidisciplinary challenge, both with respect to research and clinical management. The Center of Chronic Immunodeficiency (CCI) is dedicated to improve the basic understanding and the treatment modalities for patients with inborn or acquired immunodeficiency and to gain national and international recognition for this effort. Therefore, a new, paradigmatic, and interdisciplinary structure within the University Medical Centre will be implemented. This will enable clinicians and basic scientists, scholars and trainees to develop novel diagnostic and therapeutic modalities through insights in the molecular biology of human phenotypes and population based epidemiology. In order to achieve these aims, BMBF funding will be used to develop the following areas within the CCI: Within the CCI interdisciplinary outpatient and inpatient clinics involving specialist physicians in Paediatrics and Internal Medicine as well as Clinical Immunology and Infectious Diseases, an Advanced Diagnostics Unit developing novel tools and experimental laboratory techniques for the functional and molecular analysis of clinical immunodeficiency, and an Experimental Research Unit integrating Immunologists and Infectious Disease experts from the University Medical Centre as well as scientists from the Faculty of Biology, the Max-Planck-Institute of Immunobiology and the Transfusion Center of the University of Ulm will be implemented. Furthermore, a weekly CCI Conference will be organised as a platform for clinicians and basic researchers to discuss informative cases and to decide on binding treatment strategies for these patients, develop joint research projects and promote investigator-initiated interventional trials in order to translate basic research findings into clinical application and vice versa. The exemplary education and career development will allow trainees in medicine and biology to develop excellence in clinical practice and immunodeficiency research.
For each of these modules a specific exploitation plan is developed and the CCI management will ensures the economic basis for the sustainable integration of research and clinical care for patients with immunodeficiency.
IFB-Tx: Integrated Research and Treatment Center Transplantation
|
Medizinische Hochschule Hannover
Zentrum Innere Medizin
Klinik für Nieren- und Hochdruckerkrankungen
Carl-Neuberg-Str. 1
30625 Hannover |
Principal investigator:
Tel.:
Project number:
Volume:
Funding period:
|
Prof. Dr. Hermann Haller
+49 511 532-6319
01EO0802
24.746.380 EUR
01.07.2008 - 30.06.2013 |
Solid organ and cell-based transplantation has made considerable progress in the past years; however, graft survival remains limited and side effects of immunosuppressive medication are considerable. Moreover, mortality of transplanted patients is still unacceptably high. With the implementation of an "Integrated Research and Treatment Center Transplantation" (IFB-Tx) the Hannover Medical School plans to expand its patient-oriented research in the field of transplantation medicine to facilitate appropriate diagnostic and therapeutic changes. The integration of a large number of clinical as well as basic science departments will form the basis to address unsolved problems in transplantation medicine and to implement new diagnostic and therapeutic strategies. The large number of organ- and cell transplantations at Hannover Medical School will also facilitate large-scale interdisciplinary IFB-Tx clinical trials to strengthen international competitive clinical research in transplantation medicine and to improve treatment guidelines. The comprehensive aim of the Integrated Research and Treatment Centre IFB-Tx at the Hannover Medical School MHH is further to strengthen clinical research and academic medicine and to rectify the current deficits in clinical research structures. Additionally the IFB-Tx organizes a structured educational program designed to recruit young investigators into the field of transplantation medicine and to provide these young investigators with a professional perspective.
Center for Stroke Research Berlin (CSB)
|
Charité - Universitätsmedizin Berlin
Campus Charité Mitte
Klinik und Poliklinik für Neurologie
Charitéplatz 1
10117 Berlin |
Principal investigator:
Tel.:
Project number:
Volume:
Funding period:
|
Prof. Dr. Matthias Endres
+49 30 450 560-257
01EO0801
24.746.380 EUR
01.06.2008 - 31.05.2013 |
Being not only a life-threatening disease but also the most frequent cause of severe handicaps in adults, stroke is one of the most significant diseases in industrialized countries. Investigation and treatment of stroke requires an interdisciplinary approach in terms of a good cooperation between neuroscience and other relevant fields such as cardiology, radiology and rehabilitative medicine. All these fields are joined in the Center for Stroke Research Berlin (CSB) at the Charité - Universitätsmedizin Berlin. The CSB aims at broaden therapeutic options for stroke patients and to break new ground in structuring university medicine. The CSB establishes internal structures advancing research and improving conditions for research. These structures comprise the module Trial Team to support clinical studies, the module Experimental Labs which holds resources for basic research, the module Training which includes an extra-occupational degree program "Master of Science in Cerebrovascular Medicine", the module Health Care which includes IT and health care projects as well as the establishment of a coordinated care chain (Berlin Stroke Alliance), and the module Management which is responsible for the CSB administration, and management. CSB research groups are concerned with disease-oriented basic research, clinical research, epidemiology and health services research related to stroke. All of the CSB modules are based on individual long-term financial concepts securing sustainability of the CSB. The ,Stroke Industry-Academia-Liaison Advisory Council' assures a close link to and exchange with industry.
Stand 04.01.2012 09:52:09
